Impaired Kupffer cell function precedes development of secondary amyloidosis.

Impaired Kupffer cell function precedes development of secondary amyloidosis

It has been demonstrated previously that the acute phase reactant, serum amyloid A (SAA), is subject to degradation by surface membrane-associated proteinases of peripheral blood monocytes. However, monocytes obtained from the blood of patients with amyloidosis degraded SAA incompletely, leaving a cleavage product that, biochemically and immunologically, resembled the amyloid protein A (AA) dep...

Impaired splenic function in systemic amyloidosis.

In four cases of biopsy proven amyloidosis there was evidence of impaired splenic function. All had absent or grossly reduced splenic uptake on colloid isotope scans and three had haematological changes consistent with hyposplenism. Poor splenic function with a normal sized or enlarged spleen may be a clue to underlying amyloid.

Impaired B Cell Development and Function

Impaired cortical mitochondrial function following TBI precedes behavioral changes

Traumatic brain injury (TBI) pathophysiology can be attributed to either the immediate, primary physical injury, or the delayed, secondary injury which begins minutes to hours after the initial injury and can persist for several months or longer. Because these secondary cascades are delayed and last for a significant time period post-TBI, they are primary research targets for new therapeutics. ...

Chronic familial Mediterranean fever with development of secondary amyloidosis.

A 20-year-old Turkish male presented with fever, abdominal pain, and systemic lethargy. His clinical history revealed symptoms to be self-limiting but reoccurring over the past six months. Blood and urine specimens collected indicated renal amyloidosis. A kidney CT image indicated kidney inflammation. He was diagnosed with Familial Mediterranean Fever with the development of secondary amyloidos...